Polynucleotides

Sculptra or L-polylactic acid is a completely absorbable preparation injected under the skin to increase skin’s volume and smooth out lines and wrinkles. The results after the treatment appear gradually and are long-lasting thanks to the use of natural mechanisms of skin renewal.

AesPlla® is composed of L-polylactic acid (PLLA), the molecules of which stimulate fibroblasts to produce collagen, resulting in the replenishment of lost volume on the face or body with rebuilt tissue. PLLA is completely safe and biocompatible, eliminating the risk of allergies, as the product is absorbed by the body and ultimately degrades into CO2, H2O, and sugar. AesPlla® provides a very natural effect of filling, rebuilding, restoring density, and firmness to the skin after application.

PLLA is the most durable dermal filler among all currently FDA-approved biodegradable products!

Lenisna is a hybrid filler that combines the instant filling effect provided by hyaluronic acid and stimulates the skin to produce collagen through the use of polylactic acid. This highly effective tissue stimulator is used in aesthetic medicine to treat deep wrinkles, skin laxity, and significant tissue deficits.

Lenisna has the ability to strongly and durably stimulate collagen production responsible for the hydration, firmness, and elasticity of our skin, gradually and naturally restoring a youthful appearance.

Lenisna treatment is recommended particularly for loose and atrophic skin with a large number of fine wrinkles, low volume, or significant volume deficits. Due to the high concentration of poly D,L lactic acid 170 mg and hyaluronic acid 30 mg, Lenisna is used to increase the volume of sunken areas of the face, especially for correcting skin depressions such as:

• skin depressions,
• wrinkles and creases,
• visible signs of skin aging,
• facial sagging,
• facial skin laxity.

In addition to facial areas, we can also firm and tighten:

• inner thighs,
• abdomen,
• buttocks,
• sagging arms.

• strong, long-lasting stimulation,
• instant tissue filling result,
• rapid smoothing of wrinkles,
• no need for massage in treatment areas,
• natural and long-lasting result,
• suitable for use on face and body,

The initial results are visible immediately after the treatment due to the presence of hyaluronic acid. Collagen production occurs approximately 2 weeks after, and polylactic acid gradually but systematically rejuvenates the skin, making it denser, more elastic, and more attractive, while maintaining a natural effect.

The effects of Lenisna treatment last for at least 24 months after a series of 2-3 treatments performed every 6-12 weeks.

In order to achieve spectacular effects on the facial skin, we use Nucleofill Strong, which contains as much as 1.5 ml of 2.5% of therapeutic polynucleotides - the highest concentration of these substances available on the market.

Effects of the Strong Plus nucleotides treatment:

• Strongly stimulates fibroblasts and endogenous hyaluronic acid
• Contributes to the reconstruction of collagen and elastin
• Restores cohesion and density of the skin
• Provides the skin with a gentle lifting effect
• Smoothes wrinkles and reduces creases and folds
• Improves skin moisturization and hydration
• Shows antioxidant effects

Nucleofill Medium is a biostimulator for deep skin renewal and reconstruction. The product acts on three levels: lifting, antioxidant, and moisturizing. Nucleofill Medium contains pure polynucleotide (at a concentration of 2%), which, in a three-directional mechanism of action, stimulates the skin for rebuilding. It stimulates the production of collagen type I, elastin, and HA. The product is responsible for transforming fibroblasts into myofibroblasts through lifting, improving skin density (strong lifting).

Nucleofill Medium is intended for individuals of all ages who want to:

• achieve a visible lifting effect without interfering with facial features,
• reduce the visibility of wrinkles, lines, and firm the skin,
• apply anti-aging prophylaxis,
• minimize the effects of oxidative stress (air pollution, sun exposure, smoking, poor diet),
• moisturize the eyelids and dehydrated skin.

Nucleofill Soft Plus is a product designed for use around the eyes with a multi-directional mechanism of action.

Nucleofill Soft Plus is a naturally derived product containing highly purified polynucleotides capable of activating skin bioregeneration processes both at a deep level (adipose and bone tissue) and at the level of the dermis (fibroblast stimulation). Nucleofill Soft Plus is a potent lifting product that provides a moisturizing effect.

Indications for using Nucleofill Soft Plus:

• Reducing wrinkles around the eyes
• Improving the structure of the epidermis and thickening the dermis
• Deep biostructure of tissues

Nucleofill 20 is a modern product based on sodium DNA, specially designed for the care of young skin. Its mission is not only to intensify hydration, but also to support the skin in maintaining its elasticity and firmness. Therefore, this product is an ideal choice for those who want to delay the first signs of aging and preserve a youthful skin appearance. The key ingredient in Nucleofill 20 is polynucleotides, which are responsible for deep hydration and skin regeneration.

Nucleofill 20's action is based on the innovative use of polynucleotides, which stimulate the skin on several levels:

• Hydration and Regeneration - thanks to the presence of sodium DNA, the gel provides deep hydration and supports the skin's regenerative processes.
• Improvement of Elasticity - regular use of the product helps maintain the proper level of skin elasticity and firmness.
• Prevention of Wrinkles - Nucleofill 20 supports the skin in fighting the first signs of aging, helping to prevent the formation of wrinkles.

Application of Nucleofill 20 mesotherapy:

• filling and reducing fine lines,
• improving volume and sculpting facial contours,
• intensive skin hydration and regeneration.

Areas of application:

• face,
• neck,
• decolletage.

Nucleofill 25 represents a new generation of products based on sodium DNA, designed for intensive care of mature skin. The goal of this advanced product is not only deep hydration, but also support for natural skin renewal and firming processes, making it an ideal choice for those seeking an effective solution to combat signs of aging.

Nucleofill 25 acts innovatively by utilizing polynucleotides that stimulate the skin on multiple levels:

• Stimulation of collagen and elastin synthesis - by activating receptors on fibroblasts, the skin gains in density and elasticity, resulting in a visible lifting effect.
• Protection against oxidative stress - active metabolites neutralize free radicals, protecting the skin from harmful external factors.
• Long-lasting hydration - polynucleotides provide isoosmotic hydration of the extracellular matrix, making the skin firmer and more elastic.

Uses of Nucleofill 25:

• skin renewal and bio-restructuring,
• cellular biostimulation,
• protection against free radicals,
• deep hydration and skin lifting.

Areas of application for Nucleofill 25:

• face,
• neck,
• decolletage.

Nucleofill Eyes is a specialized product created for the delicate and demanding eye area. The formula of this product combines advanced technology and nature, offering multidimensional action: intense moisturizing, antioxidant protection, and lifting effect. The product was developed to meet the specific needs of this sensitive area, reducing signs of fatigue, wrinkles, and improving skin tone.

Nucleofill Eyes works based on innovative use of polynucleotides, which stimulate the skin on several levels:

• Biostimulation - stimulates the skin's natural regenerative processes in the eye area.
• Antioxidant and free radical action - protects the skin from the harmful effects of free radicals and external factors.
• Intense moisturization - provides deep and long-lasting moisturization to the delicate skin around the eyes.
• Reduction of puffiness - helps minimize the formation of puffiness and dark circles under the eyes.
• Strengthening of blood vessels - improves microcirculation, contributing to the reduction of dark circles and eye bags.

Application of Nucleofill Eyes:

• puffiness and dark circles under the eyes,
• wrinkles and fine lines,
• signs of aging and photoaging,
• loss of firmness and elasticity of the skin.

Nucleofill Medium Hair inhibits hair loss and stimulates hair regrowth, densifies and thickens the hair. The product stimulates angiogenesis within the hair follicles and inhibits apoptosis. The skin treated with the product undergoes biostimulation and begins to regenerate. The product is natural, safe, and does not contain substances with an allergenic potential.

Applications of Nucleofill Medium Hair:

• Biostimulation of hair follicles,
• Moisturizing the scalp,
• Support for alopecia treatment,
• Androgenic alopecia,
• Postpartum hair loss,
• Thinning eyebrows and eyelashes,
• Strengthening hair structure,
• Improving hair color.

Nucleofill Body is an innovative, fully organic gel that comprehensively targets skin imperfections. It consists of a liquid gel containing a high concentration and high molecular weight mixture of polynucleotides, combined with bio-synthetic collagenase. Thanks to its unique formula and active ingredients, it effectively reduces cellulite, stretch marks, improves skin firmness and elasticity, and reduces the thickness of fatty tissue.

How does Nucleofill Body work on the body?

• Bi lifting - the product stimulates the natural regeneration of collagen and elastin fibers, giving the skin elasticity and flexibility.
• Moisturizing - polynucleotides in the Nucleofill Body product have the ability to maintain the proper level of tissue hydration by attracting water.
• Rejuvenation - the antioxidant action of polynucleotides protects the skin from the harmful effects of free radicals, slowing down the process of premature aging.
• Anti-cellulite action - a new solution for correcting skin irregularities caused by localized obesity, cellulite, loss of firmness, and visually improving stretch marks.
• Skin rejuvenation - its targeted action allows for evening out the skin tone, reducing fat cells, and improving the appearance of cellulite, thanks to the combined action of several active ingredients.

Effects of Nucleofill Body mesotherapy:

• reduction of fatty tissue,
• body firming,
• improved skin tone,
• reduction of stretch marks and cellulite,
• restructuring and bio-restructuring of the body,
• delaying skin aging processes.

Treatment areas:

• abdomen,
• thighs,
• hips,
• inner thighs,
• inner arms.

Active ingredients:

• Dipeptide PTH 12,
• Biomimetic Peptides,
• PDRN Fragments, Collagenase,
• Deoxycholic Acid,
• Ligand,
• Tyrosine Kinase Receptors,
• Copper Tri Peptide 1,
• Tripeptide-1.