Biostimulation and skin lifting at the cellular level
Polynucleotide therapy is one of the most advanced biostimulation methods used in modern aesthetic medicine. The therapy does not mask the signs of aging nor does it change facial features – its goal is to stimulate natural regenerative processes occurring in the skin. Thanks to their action at the cellular level, polynucleotides support the reconstruction of structures responsible for firmness, elasticity, and proper tissue hydration.
Preparations based on polynucleotides act simultaneously on fibroblasts, the extracellular matrix, and antioxidant defense mechanisms. As a result, the skin gradually regains density, tightness, and a healthy appearance, and the regeneration process continues for many weeks after the treatment.
Unlike classic fillers, nucleotide therapy does not mechanically increase volume. Its task is to trigger biological renewal mechanisms, thanks to which the face looks younger, fresher, and more rested, preserving a completely natural character.
WHAT ARE POLYNUCLEOTIDES?
Polynucleotides are natural fragments of DNA and RNA nucleic acids that exhibit high biocompatibility with the human body. In aesthetic medicine, their exceptional ability to stimulate repair, regenerative, and anti-aging processes is utilized.
Scientific research indicates that polynucleotides affect the functioning of fibroblasts – cells responsible for the production of collagen, elastin, and other skin support elements. Additionally, they improve tissue hydration, support repair processes, and reduce the effects of oxidative stress and photoaging.
The most important properties of polynucleotides include:
- stimulating fibroblasts to synthesize new collagen and elastin;
- improving the quality and organization of the extracellular matrix;
- increasing the skin's ability to regenerate;
- binding large amounts of water and improving tissue hydration;
- antioxidant action and neutralization of free radicals;
- supporting repair processes after exposure to UV radiation;
- improving microcirculation and cellular metabolism.
It is precisely this multidirectional action that currently makes polynucleotides considered one of the most advanced substances used in anti-aging therapies and regenerative medicine.
HOW DOES POLYNUCLEOTIDE THERAPY WORK AND WHAT PROCESSES OCCUR IN THE SKIN?
Polynucleotide therapy does not work by mechanically filling tissues or immediately tightening the skin. Its task is to trigger natural repair and regenerative processes that occur in the dermis over the weeks following the treatment. Polynucleotides administered into the tissues create an environment conducive to cellular reconstruction, metabolic improvement, and the remodeling of the skin's support structures.
After introducing the product, a series of biological reactions occur:
- activation of fibroblasts, i.e., cells responsible for the production of collagen, elastin, and hyaluronic acid;
- stimulation of the synthesis of new collagen fibers, which are responsible for skin firmness, density, and strength;
- stimulation of elastin production, improving elasticity and the skin's ability to return to its original shape;
- intense binding of water molecules in the extracellular matrix, which increases the level of tissue hydration;
- reconstruction of the extracellular matrix, which acts as a scaffold for skin cells;
- neutralization of free radicals responsible for accelerated aging and cellular damage;
- support of repair processes occurring after exposure to UV radiation and other environmental factors;
- improvement of microcirculation and the transport of nutrients to cells;
- increasing the metabolic activity of skin cells, which accelerates their regeneration.
A special feature of polynucleotides is their ability to act simultaneously on several mechanisms responsible for aging. On the one hand, they stimulate collagen and elastin rebuilding processes; on the other hand, they protect tissues from oxidative stress and provide long-lasting skin hydration.
The biostimulation process begins immediately after the treatment, but tissue remodeling takes time. The first signs of improved hydration and skin quality usually appear after a few days, while thickening and tightening develop gradually over the following weeks and months. For this reason, polynucleotide mesotherapy is most often performed in a series of treatments, allowing the skin to reach its full regenerative potential.
WHO IS NUCLEOTIDE MESOTHERAPY FOR?
Polynucleotide therapy is used both in anti-aging prevention and in the regeneration of skin with visible signs of quality loss. The treatment works particularly well for people who expect natural rejuvenation without the effect of artificial filling.
Polynucleotide mesotherapy is recommended for:
- loss of skin firmness and elasticity;
- first and more advanced signs of aging;
- laxity of the face, neck, and décolleté;
- dehydration and dryness of the skin;
- deterioration of the facial contour;
- tired skin lacking radiance;
- photoaging;
- fine wrinkles;
- dark circles and laxity in the eye area;
- skin exposed to oxidative stress;
- regeneration after intense sun exposure;
- supporting therapy after laser treatments and other aesthetic medicine procedures.
Polynucleotides can be used preventatively as early as after the age of 30, but they are also perfectly suited for people with more advanced signs of aging.
WHAT EFFECTS CAN REALISTICALLY BE EXPECTED AFTER POLYNUCLEOTIDE THERAPY?
Polynucleotide mesotherapy triggers natural regenerative processes, which is why the effects do not appear immediately after leaving the clinic. Initially, patients most often observe an improvement in skin hydration and freshness, while the remodeling of collagen and elastin fibers develops gradually over the following weeks. The most pronounced results are achieved after completing a full series of treatments.
After the therapy, you can expect:
- gradual skin densification – over the course of a few weeks, the support fibers undergo remodeling, making the skin more compact and resistant to sagging;
- improved tension and firmness – the reconstruction of collagen and elastin allows the tissues to regain elasticity, and the facial contour becomes better defined;
- intense and long-lasting hydration – polynucleotides bind water in the extracellular matrix, improving skin comfort and its elasticity;
- smoothing of fine wrinkles and lines – the improvement in tissue quality makes the skin surface more uniform and smooth;
- brightening and evening out of the skin tone – the improvement of microcirculation and cellular metabolism gives the skin a fresher, more rested appearance;
- reduction of signs of fatigue and oxidative stress – the skin regains a healthy appearance, and the signs of chronic environmental stress become less visible;
- slowing down of aging processes – the stimulation of natural repair mechanisms supports the long-term maintenance of good skin quality.
The first effects of hydration and improved radiance may be visible after a few days, while tissue remodeling continues for 6–12 weeks after the procedure. The achieved results usually last for several months, and their longevity depends, among other things, on age, skin condition, lifestyle, hormonal balance, exposure to UV radiation, and the regularity of maintenance therapies.
Polynucleotide mesotherapy does not alter facial features and does not create an artificial filling effect. The goal of the therapy is the gradual restoration of skin quality and achieving natural, harmonious rejuvenation.
CONTRAINDICATIONS FOR POLYNUCLEOTIDE THERAPY
Each treatment is preceded by a specialist consultation, during which the condition of the skin is assessed and potential contraindications are ruled out.
The most important contraindications include:
- pregnancy and breastfeeding;
- active viral, bacterial, and fungal infections;
- skin inflammation at the treatment site;
- active herpes;
- cancerous diseases;
- uncontrolled autoimmune diseases;
- blood clotting disorders;
- use of anticoagulant medications;
- tendency to form hypertrophic scars;
- hypersensitivity to the ingredients of the preparation.
RECOMMENDATIONS AFTER POLYNUCLEOTIDE TREATMENT
Polynucleotide therapy does not require a long recovery period, however, following post-treatment recommendations allows for optimizing the skin regeneration process.
During the first few days after the procedure, it is recommended to:
- avoid saunas, swimming pools, and hot baths;
- limit intense physical exertion;
- protect the skin from UV radiation;
- use creams with a high SPF;
- avoid intense peels;
- ensure proper body hydration;
- use products recommended by a specialist.
Temporary redness, minor swelling, or small injection marks usually subside within a few days.
Threatment prices
Innovative mesotherapy stimulating and redermalizing the skin based on highly rejuvenating polynucleotides.
Biostimulators based on nucleotides are the most comprehensive and multidimensional products designed for skin rejuvenation. They act synergistically on all types of skin cells, supporting the metabolic processes occurring in them. Nucleotides in the form of nucleic acids. Their action consists of stimulating fibroblasts for intense collagen and elastin rebuilding. Polynucleotides strongly hydrate the skin and tighten it, restoring its lost volume. After the treatments, the skin becomes smoother and regains a youthful appearance.
Mesotherapy with nucleotides not only regenerates damaged tissues, but also strengthens the DNA of skin cells, increasing their resistance to oxidation and harmful factors such as ultraviolet radiation.
EFFECTS OF NUCLEOFILL MESOTHERAPY ON THE FACE:
The effect of the Nucleofill treatment is a comprehensive improvement of the skin condition:
- hydration,
- facelift,
- thickening and firming,
- smoothing out fine wrinkles,
- evening out of skin tone
- restoring the natural glow,
- reducing the effects of free radicals.
To rejuvenate the skin around the eyes, we use Nucleofill ™ Soft Plus, intended for the biorestructure of very delicate and thin tissue. It contains highly purified polynucleotides of natural origin.
RECOMMENDATIONS FOR NUCLEtids TREATMENT ON THE EYE area:
- Skin laxity
- Fine wrinkles, including the so-called Crow's feet
- Dark circles under the eyes
- Brow area lowering
- Treatment before and after procedures (lifting, blepharoplasty)
- Postoperative treatment (laser resurfacing)
Mesotherapy with polynucleotides is a modern method of skin regeneration and rejuvenation of the body, which stimulates its cellular reconstruction. The treatment acts as an advanced biostimulator, stimulating the production of collagen and elastin, as well as intensely moisturizing and densifying the skin. As a result, the skin regains firmness, elasticity, and a healthy appearance, effectively reducing visible signs of aging, sagging, or loss of tension.
How does body mesotherapy with nucleotides work?
- Polynucleotides deeply regenerate the skin, stimulating repair processes and increasing its density.
- Activation of fibroblasts leads to intensive production of collagen and elastin, improving skin firmness and tension.
- Deep moisturization and rebuilding of the skin structure make it more elastic and supple.
- Reduction of skin sagging by restoring its thickness and elasticity, counteracting the "loose skin" effect on the body.
- Improved microcirculation nourishes the skin better, oxygenates it, and gives it a healthier appearance.
- Antioxidant action protects the skin from free radicals and slows down aging processes.
Effects of body injection with nucleotides:
- The skin becomes noticeably firmer, more elastic, and denser, effectively reducing its sagging.
- Visible improvement in skin firmness, especially in problematic areas such as the abdomen, arms, thighs, or buttocks.
- Reduction of the "loose skin" effect, making the body look younger and more sculpted.
- Deep moisturization of the skin, improving its structure and healthy appearance.
- Reduced visibility of stretch marks, thanks to tissue biostimulation and regeneration.
- The skin is noticeably smoother, more supple, and uniform to the touch.
- Long-lasting firming and rejuvenating effect, lasting for many months.
Areas where polynucleotides are used on the body:
- Abdomen - improving skin firmness, reducing sagging, and making the skin more elastic after weight loss or pregnancy.
- Arms - strengthening and firming the skin, reducing "loose skin."
- Thighs - densifying the skin, reducing cellulite, and improving tension.
- Buttocks - improving elasticity, firming, and smoothing the skin structure.
- Knees and inner thighs - revitalizing the skin, restoring tension, and elasticity.
- Hands - skin regeneration, smoothing, and improving moisturization.
Mesotherapy with polynucleotides is an excellent choice for those who want to naturally rejuvenate and firm the body skin, restoring its healthy appearance and elasticity - without the use of a scalpel. ✨
Nucelofill has shown significant efficacy in the treatment of androgenetic alopecia and in all cases of hair weakening, improving the triophism of the hair follicle due to its deep and continuous biorestructure effect.
Nucelofill is indicated in all cases where the hair bulb is weakened:
- The initial stage of balding
- Androgenetic alopecia
- Pre- and postoperative treatment (transplant)
- Postpartum thinning
- Eyebrow thinning
- Thinning of the beard
We perform procedures on preparations
In order to achieve spectacular effects on the facial skin, we use Nucleofill Strong, which contains as much as 1.5 ml of 2.5% of therapeutic polynucleotides - the highest concentration of these substances available on the market.
Effects of the Strong Plus nucleotides treatment:
- Strongly stimulates fibroblasts and endogenous hyaluronic acid
- Contributes to the reconstruction of collagen and elastin
- Restores cohesion and density of the skin
- Provides the skin with a gentle lifting effect
- Smoothes wrinkles and reduces creases and folds
- Improves skin moisturization and hydration
- Shows antioxidant effects
Skin renewal and reconstruction, lifting, wrinkle smoothing, deep moisturizing, antioxidant action, and anti-aging prevention
Nucleofill Medium is a modern biostimulator designed for deep skin renewal and reconstruction, acting on three levels: lifting, moisturizing, and antioxidant. The preparation contains pure polynucleotide at a concentration of 2%, which intensely stimulates fibroblasts, promotes the production of collagen type I, elastin, and hyaluronic acid, and improves skin density and firmness.
Thanks to its unique mechanism of action, Nucleofill Medium provides a visible lifting and rejuvenating effect without interfering with the natural features of the face.
Key features
- Polynucleotides (2%) - skin rebuilding stimulation at the cellular level
- Strong lifting effect - improvement of skin density and firmness
- Deep moisturization - revitalization of even dehydrated skin
- Antioxidant action - protection against oxidative stress
- Safe and biocompatible - suitable for all ages and skin types
- Natural rejuvenation effect without altering facial features
Application
Nucleofill Medium is recommended for individuals who want to achieve a natural skin refreshment and quality improvement. Areas of application include:
- face (including the eye area)
- neck
- decollete
- hands
Effects
- Stimulation of fibroblasts for collagen type I and elastin production
- Transformation of fibroblasts into myofibroblasts (lifting effect)
- Visible wrinkle and furrow smoothing
- Improvement of skin firmness, elasticity, and moisturization
- Protection against oxidative stress
Effect Duration
On average 6-12 months, after a series of 2-3 treatments performed every 3-4 weeks
Regeneration and rejuvenation of the eye area, reduction of wrinkles, improvement of skin density and elasticity, intensive moisturizing
Nucleofill Soft Plus is an innovative biostimulating preparation dedicated to the delicate eye area, acting in multiple directions. The product is based on highly purified natural polynucleotides that activate bioregeneration processes in deep structures (adipose tissue, bone) and the dermis (fibroblast stimulation).
As a result, Nucleofill Soft Plus provides a lifting effect, densification, and moisturization, improving the overall quality and structure of the skin around the eyes.
Key Features
- Highly purified polynucleotides – strong tissue regeneration and rebuilding
- Multi-directional action – lifting, moisturizing, biorestructuring
- Intensive moisturizing and improvement of skin elasticity
- Thickening of the dermis and improvement of epidermal structure
- Safe, natural composition – minimal risk of adverse reactions
- Dedicated to the eye area – gentle and precise effect
Application
Nucleofill Soft Plus is recommended for individuals who want to improve the quality of the skin around the eyes, reduce wrinkles, and achieve a rejuvenating effect without altering facial expressions. Application areas:
- eye area (upper and lower eyelids)
- "tear trough" area
Effects
- Reduction of wrinkles around the eyes
- Lifting and densification of skin around the eyes
- Stimulation of fibroblasts for collagen and elastin production
- Improvement of skin elasticity, moisturization, and firmness
- Rebuilding of deep tissue structures
Duration of Effect
On average 6-12 months, depending on the skin condition and the number of treatments performed
Intensive moisturizing, regeneration, improvement of skin elasticity and volume, and anti-aging prophylaxis - for young, demanding skin
Nucleofill 20 is a modern biostimulating preparation based on sodium DNA, developed specifically for young skin. Its main goal is intensive moisturizing, regeneration, and maintaining elasticity and resilience, effectively delaying the first signs of aging and preserving a youthful appearance.
The key ingredient is polynucleotides, which stimulate the skin on multiple levels, supporting its natural renewal processes and strengthening its structure.
Characteristics
- Polynucleotides from sodium DNA - deep regeneration and moisturizing
- Strong moisturizing action - improvement of skin hydration in deep layers
- Enhancement of skin elasticity and resilience
- Anti-aging prophylaxis - prevention of wrinkle formation
- Safe and biocompatible - ideal for young, demanding skin
- Natural, fresh rejuvenating effect
Application
Nucleofill 20 is recommended for individuals who want to take care of young skin, improve its condition, and delay aging processes. Areas of application:
- face
- neck
- décolletage
Effectiveness
- Deep moisturizing and skin regeneration thanks to sodium DNA
- Improvement of skin elasticity and firmness
- Reduction and filling of fine lines
- Prevention of the first signs of aging
- Improvement of volume and sculpting of facial contours
Duration of Effect
On average 6-9 months, depending on age, skin condition, and number of treatments
Nucleofill 25 represents a new generation of products based on sodium DNA, designed for intensive care of mature skin. The goal of this advanced product is not only deep hydration, but also support for natural skin renewal and firming processes, making it an ideal choice for those seeking an effective solution to combat signs of aging.
Nucleofill 25 acts innovatively by utilizing polynucleotides that stimulate the skin on multiple levels:
- Stimulation of collagen and elastin synthesis - by activating receptors on fibroblasts, the skin gains in density and elasticity, resulting in a visible lifting effect.
- Protection against oxidative stress - active metabolites neutralize free radicals, protecting the skin from harmful external factors.
- Long-lasting hydration - polynucleotides provide isoosmotic hydration of the extracellular matrix, making the skin firmer and more elastic.
Uses of Nucleofill 25:
- skin renewal and bio-restructuring,
- cellular biostimulation,
- protection against free radicals,
- deep hydration and skin lifting.
Areas of application for Nucleofill 25:
- face,
- neck,
- decolletage.
Nucleofill Eyes is a specialized product created for the delicate and demanding eye area. The formula of this product combines advanced technology and nature, offering multidimensional action: intense moisturizing, antioxidant protection, and lifting effect. The product was developed to meet the specific needs of this sensitive area, reducing signs of fatigue, wrinkles, and improving skin tone.
Nucleofill Eyes works based on innovative use of polynucleotides, which stimulate the skin on several levels:
- Biostimulation - stimulates the skin's natural regenerative processes in the eye area.
- Antioxidant and free radical action - protects the skin from the harmful effects of free radicals and external factors.
- Intense moisturization - provides deep and long-lasting moisturization to the delicate skin around the eyes.
- Reduction of puffiness - helps minimize the formation of puffiness and dark circles under the eyes.
- Strengthening of blood vessels - improves microcirculation, contributing to the reduction of dark circles and eye bags.
Application of Nucleofill Eyes:
- puffiness and dark circles under the eyes,
- wrinkles and fine lines,
- signs of aging and photoaging,
- loss of firmness and elasticity of the skin.
Nucleofill Medium Hair inhibits hair loss and stimulates hair regrowth, densifies and thickens the hair. The product stimulates angiogenesis within the hair follicles and inhibits apoptosis. The skin treated with the product undergoes biostimulation and begins to regenerate. The product is natural, safe, and does not contain substances with an allergenic potential.
Applications of Nucleofill Medium Hair:
- Biostimulation of hair follicles,
- Moisturizing the scalp,
- Support for alopecia treatment,
- Androgenic alopecia,
- Postpartum hair loss,
- Thinning eyebrows and eyelashes,
- Strengthening hair structure,
- Improving hair color.
Reduction of body fat and cellulite, firming and densifying of the skin, improvement of skin tone, reduction of stretch marks, tissue remodeling and restructuring
Nucleofill Body is an innovative, fully organic biostimulating preparation designed for body contouring and improving the quality of the skin. Thanks to an advanced formula based on high-concentration and high-molecular-weight polynucleotides, enriched with biosynthetic collagenase and a complex of biomimetic peptides, the preparation works on multiple levels effectively.
Characteristics
- Polynucleotides - intense biostimulation and skin reconstruction
- Strong anti-cellulite and anti-stretch mark action
- Deep moisturizing and improvement of elasticity
- Lifting and firming effects
- Antioxidant protection and rejuvenating action
Mechanism of Action
Nucleofill Body's action is based on the innovative use of polynucleotides, which stimulate the skin on multiple levels:
- Biolifting - the preparation stimulates the natural rebuilding of collagen and elastin fibers, giving the skin elasticity and flexibility.
- Moisturizing - the polynucleotides in Nucleofill Body have the ability to maintain the proper level of tissue hydration by capturing water.
- Rejuvenation - the antioxidant action of polynucleotides protects the skin from the harmful effects of free radicals, thus inhibiting the process of premature aging.
- Anti-cellulite action - a new solution for correcting skin unevenness caused by localized obesity, cellulite, loss of firmness, and visually improving stretch marks.
- Skin rejuvenation - its targeted action allows for evening out skin tone, reducing fat cells, and improving the appearance of cellulite, through the combined action of several active ingredients.
Application:
- reduction of body fat,
- body firming,
- improvement of skin tone,
- reduction of stretch marks and cellulite,
- body remodeling and bio-restructuring,
- delaying skin aging processes.
Treatment Areas:
- abdomen,
- thighs,
- hips,
- inner thighs,
- inner arms.
Duration of Effect
On average 6-12 months, after a series of 3-4 treatments every 3-4 weeks
Injection regenerative therapy with polynucleotides dedicated to the delicate eye area – reduction of dark circles, improvement of skin quality, and anti-aging action at the cellular level.
PLINEST® EYE is a medical injectable product based on highly purified polynucleotides (PN-HPT®), intended for the revitalization of the thin and demanding skin around the eye. The product belongs to the group of so-called tissue biostimulators – its action is not based on mechanical filling but on the activation of the skin's natural repair processes:
- stimulation of fibroblasts
- improvement of microcirculation
- increasing the synthesis of collagen and elastin
- antioxidant action
The product is especially dedicated to areas where classic hyaluronic acid fillers can result in excessive volume or swelling.
Characteristic Features
- PN-HPT® technology (Highly Purified Technology)
- fraction of polynucleotides with a high degree of purification
- product exclusively dedicated to the eye area
- regenerative action, not volumetric
- improvement of skin quality without the "overdrawn" effect
The product is sterile, ready for intradermal or very superficial subcutaneous application, according to the manufacturer's recommendations.
Main Active Ingredients
- Polynucleotides (PN-HPT®)
- DNA fragments with high biocompatibility
Action:
- strong stimulation of fibroblasts
- increased production of type I collagen
- improvement of skin elasticity
- anti-inflammatory action
- reduction of oxidative stress
Polynucleotides exhibit reparative properties by activating adenosine receptors and improving cellular metabolism.
Application
PLINEST® EYE is used in the therapy of:
- dark circles under the eyes (especially vascular and atrophic origin)
- looseness of the lower eyelid skin
- fine periocular wrinkles
- thin, dehydrated, and tired skin
- prevention of aging in the eye area
It can be used alone or as part of combined therapies (e.g., with mesotherapy, fractional laser therapy, light therapy).
Clinical Effects
Based on manufacturer data and studies on polynucleotides:
- improvement of skin tension and density
- reduction of fine wrinkles
- brightening of dark circles under the eyes
- improvement of hydration and elasticity
- reduction of photoaging symptoms
The effect is not immediate – it develops gradually as a result of tissue remodeling processes.
Duration of Effects
- protocol: usually 2–4 sessions at intervals of 2–3 weeks
- initial effects: after 2–3 weeks
- full effect: after completing the series
- maintenance: on average 6–9 months (depending on the patient's age and skin quality)
The product works biologically – therefore, the duration of the effect depends on the body's regenerative abilities, lifestyle, and potential maintenance therapies.
Regenerative Injection Therapy with Polinucleotides PN-HPT® – Skin Quality Restoration through Activation of Natural Repair Processes.
PLINEST® is a medical injectable preparation based on highly purified polynucleotides (PN-HPT®), designed for the biostimulation and regeneration of facial and body skin.
Its action is not based on mechanically filling tissues but on stimulating fibroblasts and remodeling the extracellular matrix. The preparation improves skin quality physiologically – by supporting repair processes, improving microcirculation, and providing antioxidant effects.
This is a solution for patients who expect real improvement in skin structure, not just a short-term tightening effect.
Characteristic Features
- PN-HPT® technology (Highly Purified Technology)
- high degree of polynucleotide purification
- biostimulating, not volumetric action
- strong regenerative and antioxidant properties
- suitable for use on the face and body
- high safety and biocompatibility profile
The preparation is administered intradermally or subcutaneously according to the manufacturer's protocol.
Main Active Ingredients
Polynucleotides (PN-HPT®)
Highly purified DNA fragments with high biological biocompatibility, exhibiting:
- stimulation of fibroblast proliferation
- increased synthesis of type I collagen
- improvement in skin elasticity and density
- anti-inflammatory effects
- reduction of oxidative stress
- support for tissue repair processes
The mechanism of action includes the activation of adenosine receptors and the improvement of cellular metabolism.
Applications
PLINEST® is used in the therapy of:
- loose and thin skin
- early and moderate signs of aging
- photoaging
- loss of elasticity in the face, neck, and décolleté
- dehydrated skin with reduced density
- scars and stretch marks
- regeneration after laser treatments and medical peels
It can be used as a standalone therapy or as part of a combined therapy.
Clinical Effects
Based on studies on polynucleotides and manufacturer data, the following observations are made:
- improvement in skin tension and elasticity
- increase in skin density
- smoothing of fine wrinkles
- improvement in hydration
- evening out of skin texture
- accelerated regeneration after ablative treatments
The effects develop gradually – the preparation initiates a process of biological remodeling, resulting in a natural and progressive outcome.
Durability of Effects
- recommended series: 2–4 treatments every 2–3 weeks
- first effects: after approximately 2–3 weeks
- full effect: after completion of the series
- maintenance: on average 6–9 months
In clinical practice, the durability depends on the patient's biological age, skin quality, and lifestyle. A reminder therapy 1–2 times a year helps maintain the regenerative effect.
Intensive skin and tissue regeneration using highly purified polynucleotides PN-HPT® – a reparative therapy for skin requiring strong stimulation.
PLINEST® ONE is an injectable medical preparation based on PN-HPT® (Highly Purified Technology) technology, containing a high concentration of polynucleotides. It has been developed as a product with increased concentration of the active substance compared to the classic PLINEST®, intended for intensive tissue regeneration.
The preparation acts biologically – not through a filling effect, but by initiating skin repair processes. It stimulates fibroblasts, improves cellular metabolism, and supports the rebuilding of the extracellular matrix.
This solution is dedicated to skin with signs of advanced aging, loss of elasticity, and after intensive aesthetic procedures.
Characteristic features
- high concentration of polynucleotides (PN-HPT®)
- high purification technology – minimal risk of immunological reactions
- strong regenerative and antioxidant effects
- improvement of skin quality without volumetric effect
- suitable for use on face and body
The product is intended for intradermal or subcutaneous administration according to the manufacturer's protocol.
Main active ingredients
Polynucleotides (PN-HPT®) - Highly purified DNA fragments with strong biological potential:
- stimulate fibroblast proliferation
- increase type I collagen synthesis
- improve angiogenesis and microcirculation
- have anti-inflammatory effects
- reduce oxidative stress
The mechanism of action includes the activation of adenosine receptors and the support of DNA repair processes in skin cells.
Application
PLINEST® ONE is used in the therapy of:
- flaccid and atrophic skin
- advanced photoaging
- loss of firmness on face, neck, and décolletage
- skin after intensive treatments (laser therapy, medical peels)
- stretch marks and scars
- anti-aging prevention in patients with thin, biologically weakened skin
It can be used as a standalone biostimulating therapy or as part of a combined treatment plan.
Clinical effects
Based on the manufacturer's data and studies on polynucleotides:
- improvement in skin tension and elasticity
- increased skin density
- smoothing of fine wrinkles
- improvement in hydration
- evening out of skin structure
- acceleration of regenerative processes after ablative procedures
The effect builds gradually – the product initiates tissue remodeling rather than providing immediate volume.
Duration of effects
- recommended series: 2–3 treatments at 2–3 week intervals
- first visible effects: after 2–4 weeks
- full remodeling: after completing the series
- maintenance of effects: on average 6–12 months
Duration depends on the biological age of the patient, lifestyle, and maintenance therapies.
Comprehensive skin rejuvenation, rebuilding, and intensive moisturizing, improving firmness and elasticity
This innovative treatment cocktail combines the greatest achievements of modern aesthetic medicine in one formula, creating the most powerful regenerative and rejuvenating treatment in its category. Thanks to the unique combination of low-molecular-weight hyaluronic acid, polynucleotides, hydrolyzed collagen, and amber acid, the preparation acts on multiple levels, providing immediate effects in improving skin firmness, tension, and quality.
Key features
- Low-molecular-weight hyaluronic acid - intense, deep moisturizing and rebuilding of the extracellular matrix
- Polynucleotides - three-dimensional moisturization, stimulation of fibroblasts, and rebuilding of collagen and elastin
- Hydrolyzed collagen - strengthening skin autoregeneration, initiation of type I pro-collagen synthesis, and elastin fiber
- Amber acid - stimulation of microcirculation, protection against oxidative stress, anti-inflammatory action
- Advanced bio-compatibility and safety
Action of active ingredients
Hyaluronic acid
- Deeply moisturizes
- Rebuilds the extracellular matrix
- Supports natural regenerative processes
Amber acid
- Stimulates fibroblasts for collagen and elastin production
- Protects tissues against oxidative stress
- Improves microcirculation and diffusion of active ingredients
- Has anti-inflammatory properties and supports sensitive skin therapy (e.g., rosacea)
Hydrolyzed collagen
- Initiates the synthesis of new collagen and elastin
- Densifies and strengthens the skin
- Intensifies autoregeneration processes
Polynucleotides
- Strongly hydrate and bind water
- Stimulate fibroblasts and support the regeneration of damaged tissues
- Protect against protein glycation and UV radiation
Application
- Improving skin firmness and tension
- Reducing wrinkles and lines
- Rebuilding and densifying tissues
- Biological skin rejuvenation
- Intensive moisturizing and regeneration
- Support for sensitive skin therapy (e.g., rosacea)
- Immediate improvement in skin appearance and tension
- Visible reduction of wrinkles
- Long-lasting rejuvenation and tissue densification
Duration of effect
On average 6-9 months, depending on skin condition, lifestyle, and the number of treatments performed (recommended series of 3-4 treatments every 3-4 weeks)