Nucleofill or Profhilo?

05.09.2025
In today's world of aesthetic medicine, tissue bio-stimulators are gaining popularity, with the two most advanced ones being Nucleofill and Profhilo. Both products, although aimed at deep skin renewal without changing facial features, differ in composition and mechanism of action. Nucleofill works through polynucleotides that stimulate the production of type I collagen, while Profhilo utilizes a high concentration of hyaluronic acid. Find out when it's best to use each of them!

What are Nucleofill and Profhilo and how do they work?

Nucleofill and Profhilo are modern tissue bio-stimulators widely used in aesthetic medicine. Their main task is deep skin renewal. They work by stimulating fibroblasts - cells responsible for the production of collagen and elastin. Nucleofill provides lifting, antioxidant action, as well as intense moisturizing and support for skin regeneration. On the other hand, Profhilo focuses on tissue bioremodeling, restoring the skin's natural scaffolding. Both preparations effectively initiate biorevitalization processes, leading to natural skin rejuvenation and improving its condition without altering facial features.

What are the main differences in composition and mechanism of action?

The key differences between Nucleofill and Profhilo stem from their composition and mechanism of action. Nucleofill is based on natural polynucleotides, which are fragments of DNA and RNA. These activate fibroblast receptors, intensely stimulating the production of type I collagen. Additionally, these bioactive molecules act as antioxidants, neutralizing free radicals and reducing oxidative stress. Furthermore, they bind water, ensuring good skin hydration.

Profhilo is based on unique, stabilized complexes of hyaluronic acid at a high concentration (64 mg). The secret to its effectiveness lies in the slow, gradual penetration of hyaluronic acid deep into the tissues, providing:

  • Intensive skin hydration,
  • Stimulation of fibroblasts to produce collagen and elastin,
  • Effective tissue remodeling,
  • Restoration of the skin's natural scaffolding.
When to choose Nucleofill and when to choose Profhilo?

The choice between the treatments Nucleofill and Profhilo is always an individual matter, strictly dependent on the condition of the patient's skin. The final decision is made by the doctor during a detailed consultation with the patient.

Nucleofill is the ideal solution for dehydrated, poorly oxygenated, and skin exposed to oxidative stress. It effectively slows down the appearance of the first signs of aging. Moreover, its special variants effectively reduce dark circles and puffiness under the eyes, providing a comprehensive improvement in the appearance of delicate eye areas.

Profhilo is suitable when the problem is significant skin sagging, loss of facial contour, or the appearance of so-called "marionette lines." This innovative product actively remodels tissues, rebuilding the skin's natural scaffolding. As a result, it provides a strong lifting effect and significantly improves skin tension, restoring a youthful appearance.

What effects can be expected from both procedures?

The Nucleofill treatment visibly firms and elasticizes the skin. Thanks to it, the skin regains a uniform tone, and fine lines become less visible. Profhilo works differently, focusing on sculpting facial contours. It not only smooths wrinkles but also gives the skin a unique glow, often referred to as the "wet skin" effect. Both treatments provide natural and gradual skin rejuvenation. Their long-lasting results are the effect of deep, internal skin restructuring.

How do Nucleofill and Profhilo procedures differ and what is the process for each?

The treatments Nucleofill and Profhilo, although both effectively revitalizing the skin, differ primarily in the techniques of applying the products.

Profhilo is administered using an innovative method called BAP (Bio Aesthetic Points), which involves just five precise injections on each side of the face. This approach minimizes the patient's discomfort and significantly shortens the recovery time after the procedure.

Nucleofill is administered differently. It can be applied to bioaesthetic points using a needle or a cannula, often resulting in a higher number of punctures. Due to the way the product is applied, the treatment somewhat resembles mesotherapy. Regardless of the chosen product, a single treatment session is always quick.

To achieve optimal and long-lasting results, specialists usually recommend a series of treatments at specific intervals.

What are the contraindications and possible side effects of procedures?

Nucleofill and Profhilo procedures are widely considered safe and usually well-tolerated by patients. However, it is always necessary to have an initial consultation with a doctor to rule out any contraindications to these procedures. Key contraindications include:

  • Pregnancy,
  • Breastfeeding,
  • Active cancer,
  • Untreated autoimmune diseases,
  • Active skin infections such as herpes in the area of the planned procedure,
  • Tendency to form keloids,
  • Blood clotting disorders.

Any potential side effects after the procedures are usually mild and quickly resolve. Commonly observed effects include redness, slight swelling, tenderness, or minor bruising at the injection site. Serious complications are extremely rare. Recovery after the procedure is short, allowing patients to quickly return to their daily activities.

How much do the treatments cost and how long do the effects last?

The price of treatments depends on several important factors, such as the type of chosen product, the location of the office, and the experience of the specialist. To achieve optimal and lasting results, a series of treatments are often recommended, which affects the total cost.

With Profhilo, effects are usually visible for 12-18 months. In the case of Nucleofill, results often last for many months, sometimes even up to 1 year.