NAD+

NAD+ is a coenzyme found in all living cells. Its primary function is to participate in redox reactions, i.e., electron transfer processes necessary for energy production in mitochondria. In practice, this means that NAD+ enables cells to produce ATP – the body's main „energy fuel.”

This coenzyme exists in two forms:

• NAD+ – oxidized form,
• NADH – reduced form.

The balance between these forms determines proper cellular metabolism. NAD+ participates, among others, in:

• glycolysis,
• the Krebs cycle,
• oxidative phosphorylation,
• DNA synthesis and repair,
• regulation of oxidative stress,
• activation of sirtuin enzymes and PARP.

The body synthesizes NAD+ primarily from vitamin B3 (niacin), nicotinamide, and tryptophan. With age, the body's ability to maintain adequate levels of this coenzyme gradually decreases.

Modern aesthetic and regenerative medicine increasingly utilize therapies supporting cellular metabolism and mitochondrial functions, as the aging of skin and tissues is closely related to the decline in cellular energy efficiency.

One of the most important functions of NAD+ is its involvement in DNA damage repair processes. Every day, the genetic material of cells is exposed to:

• UV radiation,
• free radicals,
• environmental toxins,
• chronic inflammation,
• metabolic stress.

DNA repair requires the activity of PARP enzymes (Poly ADP-ribose Polymerase), which use NAD+ to function. When the level of the coenzyme is low, regenerative processes are weakened, and cells transition into a state of biological aging faster.

NAD+ also activates sirtuins – proteins that regulate cellular longevity, energy metabolism, and resistance to oxidative stress. Sirtuins affect:

• mitochondrial function,
• inflammation control,
• tissue regeneration,
• metabolic processes,
• protection of nerve cells.

The particular importance of NAD+ is observed in tissues with high energy demand:

• the brain,
• muscles,
• the heart,
• the liver,
• the skin.

In aesthetic dermatology and anti-aging medicine, increasing attention is being paid to the role of mitochondria in the process of skin aging. Energy dysfunction of skin cells affects the decline in collagen production, deterioration of regeneration, and greater susceptibility to oxidative stress.

Supporting proper NAD+ levels primarily relies on actions affecting mitochondrial metabolism and reducing chronic oxidative stress.

The most important factors supporting NAD+ synthesis include:

Diet rich in NAD+ precursors

Ingredients containing vitamin B3 and compounds involved in energy metabolism are important:

• fish,
• eggs,
• meat,
• fermented products,
• green vegetables,
• legumes.

Physical activity

Regular exercise increases mitochondrial biogenesis and improves cellular energy management. Aerobic and interval training show a particularly beneficial effect.

Sleep and regeneration

Chronic sleep deprivation increases oxidative stress and the consumption of NAD+ by the body's repair mechanisms.

Limiting chronic inflammation

Excessive activation of the immune system leads to increased consumption of NAD+ by enzymes responsible for the inflammatory response.

Therapies supporting the body's cellular regeneration

In regenerative and anti-aging medicine, increasing attention is paid to therapies supporting cellular metabolism, mitochondrial function, and the body's natural repair mechanisms. The goal of these actions is to improve cellular energy production, reduce oxidative stress, and support processes related to maintaining proper NAD+ levels.

Therapies supporting cellular regeneration include, among others:

• infusion therapies supporting cellular metabolism,
• actions supporting mitochondrial function,
• therapies reducing oxidative stress and chronic inflammation,
• procedures improving microcirculation and tissue oxygenation,
• regenerative and biostimulating therapies.

Therapies supporting skin cellular metabolism

In aesthetic dermatology and anti-aging medicine, increasing attention is paid to therapies supporting the functioning of skin cells, fibroblasts, and mitochondria. Skin aging is associated not only with a decrease in the amount of collagen but also with deterioration of cellular energy metabolism and increased oxidative stress.

Procedures supporting the regeneration and metabolic activity of the skin include, among others:

• biostimulating treatments – tissue stimulators stimulate fibroblasts to produce collagen, elastin, and extracellular matrix components, supporting the skin's natural reconstruction and regeneration processes;
• regenerative mesotherapy – delivers active substances to the skin, such as amino acids, peptides, hyaluronic acid, antioxidants, and vitamins involved in cellular metabolism;
• fractional laser therapy – causes controlled micro-damage to the skin, activating intensive repair processes and collagen remodeling;
• microneedling radiofrequency – combines microneedling with radiofrequency energy, stimulating tissue regeneration and improving skin density;
• antioxidant therapies – help limit oxidative stress responsible for cellular damage, accelerated skin aging, and mitochondrial dysfunction;
• procedures improving microcirculation and skin oxygenation – support the transport of oxygen and nutrients necessary for proper cell functioning and effective tissue regeneration.

In modern aesthetic medicine, combined therapies are increasingly used, aiming to simultaneously stimulate regenerative processes, improve cellular metabolism, and limit mechanisms responsible for biological skin aging.

The offer includes modern aesthetic and regenerative medicine procedures that support skin condition, repair processes, and biological mechanisms of healthy aging.