Platelet-rich fibrin I-PRF

Platelet-rich fibrin is a new-generation platelet concentrate that is obtained from the patient's blood by collecting it and then centrifuging it. The material is rich in stem cells and growth factor-producing platelets. Fibrin differs from platelet-rich plasma in that it has a cross-linked, three-dimensional structure, thanks to which it creates a mesh at the injection site that supports the skin and stimulates the subcutaneous tissue to renew, giving the effect of gentle filling (volumetry), and the platelets contained in it for a long time are stimulated to secreting growth factors rebuilding the skin structure.

The effect of platelet-rich fibrin on tissues is based on two basic mechanisms:

First of all, thanks to the content of a large amount of growth factors, it stimulates various types of regenerative processes in tissues. As a result, there are a number of benefits in terms of improving the firmness, vitality and health of tissues (e.g. skin).
The second mechanism is the action of platelets, i.e. thrombocytes, which, apart from their obvious function of ensuring proper blood clotting, also secrete significant amounts of growth factors, which additionally support the activity of those factors that are already present.
Platelet-rich fibrin is used for comprehensive biostimulation and skin rejuvenation. The treatment regenerates collagen and elastin fibers responsible for keeping the skin in good condition, making it an excellent method of rejuvenating and improving the appearance of the face. It improves the firmness and elasticity of the skin, thickens it, removes wrinkles and nasolabial folds, definitely rejuvenates the face oval and the eye area. It also works to improve the appearance of more delicate and difficult areas such as the neck, cleavage or hands. It is also very effective in treating baldness or removing scars, especially hypertrophic ones, as well as removing stretch marks.

The preparation is natural, safe and does not cause allergic reactions.

Natural stimulation of hair growth and scalp rejuvenation

Treatment using I-PRF, a platelet-rich fibrin, is an innovative autologous regenerative therapy that effectively stimulates hair growth, improves scalp condition, and supports combating hair loss. With a high concentration of platelets, stem cells, and growth factors, I-PRF acts directly at the site of the problem – stimulating hair follicles, improving microcirculation, and accelerating regenerative processes within the scalp.

It is an excellent alternative for individuals who want to halt hair loss and thicken their hair in a completely natural way without burdening the body with synthetic substances.

How does I-PRF work on the scalp?

During the procedure, platelet-rich fibrin is isolated from the patient's blood – a substance with a gel-like consistency containing:

• Concentrated platelets
• CD34+ stem cells
• Growth factors (PDGF, VEGF, TGF-β)

Injected into the scalp, I-PRF works on three levels:

• Stimulates hair follicles – accelerating the hair transition from the resting phase (telogen) to the growth phase (anagen)
• Improves scalp blood flow – delivering more oxygen and nutrients to hair follicles
• Regenerates the scalp – supporting the treatment of inflammatory conditions, normalizing skin functions, and strengthening its structure

The result is a noticeable reduction in excessive hair loss, strengthening of hair, and gradual thickening.

Who is the treatment recommended for?

The I-PRF treatment for the scalp is recommended for individuals who:

• Have noticed excessive hair loss (both sudden and chronic)
• Are dealing with androgenic alopecia (both men and women)
• Are experiencing hair weakening and thinning due to stress, pregnancy, hormonal disorders, or infections
• Want to strengthen transplanted hair or prepare for transplantation
• Seek an alternative to pharmacological therapy and synthetic trichological preparations
• Have a scalp prone to inflammatory conditions, flaking, or dryness

Effects of the I-PRF treatment on the scalp:

• Reduction in excessive hair loss → by activating hair follicles and improving their nutrition
• Acceleration of new hair growth → noticeable hair thickening within 8-12 weeks
• Strengthening hair structure → hair becomes thicker, stronger, and more resistant to external factors
• Improved scalp blood flow → better oxygenation and metabolism of hair follicles
• Normalization of skin functions → alleviation of inflammation, reduced itching, improved moisturization
• Long-term regenerative effects → thanks to gradual release of growth factors
• Possibility of combining with other trichological therapies → e.g., mesotherapy, carboxytherapy, biomimetic peptides

Treatment frequency

• A single treatment can effectively support scalp condition, especially after an acute episode of hair loss.
• For optimal results, a series of 3-4 treatments every 3-4 weeks is recommended, followed by maintenance treatments every 6 months.

Why is it worth it?

I-PRF treatment is a safe and effective method for scalp rejuvenation and hair growth stimulation. As an autologous therapy – based solely on components derived from the patient's own blood – it is free from allergy risks and side effects, while being in line with the body's natural physiology.

It is an ideal solution for individuals looking for natural but advanced methods to combat hair loss and hair weakening.

Autologous next-generation tissue filler

The SKIN UP procedure is an innovative regenerative medicine treatment that harnesses the potential of a patient's own blood to rebuild volume and structure in the skin. It serves as an alternative to traditional synthetic fillers - completely biocompatible, safe, and natural. Thanks to modern technology for plasma separation and thermal processing, an autologous gel with consistency and properties similar to hyaluronic acid fillers is obtained, but without the risk of allergic reactions, swelling, or overcorrection.

SKIN UP is not just an aesthetic procedure but primarily a regenerative therapy that activates the skin's natural repair processes. Growth factors in platelet-rich plasma activate fibroblasts to produce collagen, elastin, and hyaluronic acid, leading to lasting strengthening and densification of tissues. As a result, the skin regains youthful elasticity, firmness, and volume, with facial features becoming harmonious and rested.

The procedure is performed in one visit - fully autologous, sterile, and safe. The resulting material can be used in various areas: from facial contouring, cheek corrections, nasolabial folds, temple and jawline areas, to lip revitalization or hand rejuvenation.

How the procedure works - mechanism of action

Below is a step-by-step description of the process:

• Patient's blood collection - usually 10-20 ml.
• Centrifugation of blood in special tubes to obtain platelet-rich plasma (PRP).
• Subsequently, part of the plasma undergoes a heating process ("gelling") in a dedicated device such as the "Plasma Gel Maker" at around 80°C for about 10 minutes, followed by cooling for about 8 minutes - resulting in autologous gel with the right consistency.
• Material homogenization by passing through syringes - allows for obtaining various versions (hard, medium, soft) depending on the area's needs.
• Introduction of the resulting autologous gel - usually with a cannula or needle - into the selected facial and/or body areas for volume correction, contouring, and tissue regeneration.

The mechanism of action is based on both volumizing (filler gel filling gaps) and regenerative action (growth factors, platelet-rich plasma stimulating tissue repair).

Who is the procedure recommended for and what issues can it address?

This procedure is particularly recommended for individuals who:

• Have visible loss of skin volume (e.g., in cheek, temple, or jaw areas).
• Observe sagging of facial contours - jawline sagging, nasolabial folds.
• Desire a "soft lifting" effect without synthetic fillers.
• Have thin skin prone to swelling or are allergic/unwilling to use traditional hyaluronic acid-based fillers.
• Want to improve the condition of hands, lips - areas challenging for traditional filling therapy.
• Are willing to invest in regenerative treatments that combine aesthetic effects with skin structure improvement.

The procedure does not replace surgical facelift - in cases of advanced sagging or deep wrinkles, combination with other technologies may be necessary.

Skin types

The treatment can be used on most skin types - particularly beneficial if the skin is:

• Thin, with visible subcutaneous tissue loss;
• Beginning to lose firmness or volume ("structural wrinkles", sagging jawline);
• Prone to swelling with traditional fillers - in such cases, autologous material may be a better choice.

As an expert, I emphasize that each skin requires individual assessment - a consultation with a cosmetic doctor will help determine: the product variant (soft/medium/hard), application technique, and potential combination with supporting therapies.

Effects of the SKIN UP procedure

• Visible facial volume rebuilding - e.g., in cheek or temple areas, with autologous gel filling → the result is natural as it comes from the patient's blood.
• Improvement of facial contour - the jawline becomes more defined, "chubby cheeks" reduce → the skin looks younger and more harmonious.
• Smoothing wrinkles and skin folds - autologous gel and growth factors support tissue repair, leading to less visible mimic lines.
• Enhancement of skin density and quality - platelet-rich plasma content makes the skin firmer, more elastic, with better tension.
• Very good tolerance - as the material is autologous, the risk of allergic reactions or swelling is lower than with some synthetic fillers.
• Regeneration effect - besides filling, the skin is biologically stimulated for repair and structural strengthening → result is not only aesthetic but also functional.
• Possibility of application in various areas - from the face, through lips, hand dorsum, to contouring smaller body parts - thanks to the ability to vary the gel's consistency.

Frequency of treatments (usage plan)

To ensure optimal and lasting results, I recommend the following plan:

• First treatment as a full material application - covering the indicated area.
• After about 3 months, evaluate the effect and possibly supplement - especially if some autologous material has been partially resorbed.
• Typically, after 2-3 treatments (spaced around 3 months), we achieve an effect lasting about a year.
• In the following years, the treatment can be repeated once a year or as per individual dermatological assessment.

Each plan is determined by a specialist - considering the patient's age, skin condition, expectations, and treatment technique.

Number of areas that can be treated depending on the amount of autologous filler used

The treatment range depends on the amount of used filler, which is measured in syringe-ampoules. This allows for precise therapy adjustment to skin needs and the desired aesthetic effect.

• 1 syringe - enables treatment of 1 larger area (e.g., cheeks, neck, forehead, décolletage) or 2 smaller areas (e.g., eye area + nasolabial fold).
• 2 syringes - allow for comprehensive facial therapy (e.g., cheeks + eye area + forehead) or face and neck, providing significant skin smoothing and density improvement.
• 3 syringes - enable full revitalizing therapy for face, neck, and décolletage or face and hands, offering rejuvenation effect on multiple areas simultaneously.

Example: Simultaneous treatment of cheeks, tear troughs, and chin - to achieve a natural smoothing and shaping effect on the lower face - typically requires 2-3 syringes, depending on the initial skin condition and expected results.

During the consultation, the specialist will assess skin needs precisely and propose an optimal treatment plan - to achieve a harmonious, natural effect without overcorrection.

Why choose the SKIN UP procedure?

Choosing SKIN UP is a conscious decision - it combines aesthetics with regenerative medicine, providing an advantage over traditional fillers:

• The material comes from the patient's blood - minimizing reaction risks and increasing safety.
• The effect is not only filling but also regenerative - meaning the skin not only looks better but functions better.
• You can adjust the consistency (hard/medium/soft) and technique, achieving a natural look without an "overfilled" effect.
• Excellent option for patients with filler allergies, tendency to swell, or desiring comprehensive anti-aging action.
• In our clinic, Ambasada Urody Clinic & Spa in Warsaw, we provide thorough diagnostics, protocol selection, and full post-treatment support - ensuring client comfort and peace of mind.

By choosing SKIN UP, you invest in long-term effects - not only visual but also structural and skin health benefits.

Natural Skin Rejuvenation and Advanced Skin Regeneration

Autologous treatments based on platelet-rich fibrin I-PRF are one of the most effective methods of natural rejuvenation and skin reconstruction, highly valued in both aesthetic and regenerative medicine. A series of 3 I-PRF treatments allows for intensive tissue remodeling - not only smoothing wrinkles but also regaining volume and skin quality in challenging areas such as tear troughs, neck, eyelids, and décolletage.

How does PRP + I-PRF therapy work?

The treatment combines two autologous fractions of the patient's blood:

• Platelet-Rich Plasma (PRP) - contains concentrated blood platelets that immediately activate fibroblasts and other skin cells for regeneration, increase collagen production, and improve microcirculation.
• Platelet-Rich Fibrin (I-PRF) - a modern, three-dimensional form of slow-releasing gel matrix that not only acts regeneratively but also creates a biological "scaffolding" for tissues, gently filling and rebuilding volume.

The result? Synergistic action in the superficial and deep layers of the skin: immediate improvement in firmness and complexion, as well as long-term tissue remodeling.

Who is the series of 3 treatments recommended for?

A series of 3 PRP + I-PRF treatments is recommended for patients who:

• observe progressive signs of skin aging - wrinkles, furrows, sagging, loss of contour
• want to improve the quality of thin, delicate, dehydrated skin - neck, eyes, décolletage
• notice volume loss in areas such as tear troughs, cheeks, temples
• deal with acne scars, stretch marks, or early signs of hair loss
• prefer natural regeneration methods - without artificial substances and the risk of allergies
• expect not only improvement in appearance but also deep structural renewal

Skin Types

The therapy is suitable for:

• thin, atrophic, sagging skin
• dry, dehydrated skin with lost elasticity
• sensitive and reactive skin (due to the autologous nature of the preparation)
• mature skin with signs of photoaging
• skin after intensive dermatological or laser treatments requiring reconstruction

Effects of a series of 3 PRP + I-PRF treatments:

• Visible smoothing of mimic wrinkles and furrows - around the eyes, lips, tear troughs, forehead, and neck
• Improvement in facial contour and lift - subtle lifting effect without surgery
• Skin densification and thickening - better tissue structure, thickness, and resilience, especially in sagging areas
• Reduction of fatigue signs and dull complexion - skin becomes radiant and better oxygenated
• Rebuilding tissue volume - especially in sunken facial areas like cheeks, temples, under the eyes
• Evening out skin tone and reducing shadows - improved microcirculation, brightening around the eyes and cheeks
• Long-lasting skin bio-stimulation - thanks to the slow release of growth factors from fibrin
• Improvement in skin quality in challenging areas - décolletage, neck, lower eyelids
• Rejuvenation and densification of the skin around the eyes - the "open-eyed" effect without the risk of swelling
• Regeneration of tissues affected by acne scars, stretch marks, or hair thinning - improving skin texture and color and stimulating hair follicles
• Natural filling effect without "artificial" volume - the face looks healthy, fresh, but not overdone

Frequency and therapy plan

• For optimal results, a series of 3 treatments is recommended at intervals of 4-6 weeks.
• The effects deepen over time and are long-lasting, allowing natural tissue remodeling to continue even 6-12 months after therapy completion.
• Reminder treatment: every 6-12 months

Why opt for a series of 3 PRP + I-PRF treatments?

• It is the most comprehensive form of skin regeneration - natural, safe, and effective.
• The treatment series not only improves external appearance but genuinely rebuilds skin structure.
• The procedure uses only your cells and plasma, making the risk of allergic reactions nonexistent.
• The effects are multi-level and long-lasting - from better complexion to real skin densification and rejuvenation.
• It is an ideal therapy for those who want to regain freshness and a youthful look without synthetic fillers.

Do you want to restore volume, firmness, and a healthy glow to your skin - without artificial substances and invasive procedures? A series of 3 treatments with I-PRF fibrin is a biological response to your skin's needs - natural, deep, and safe. Visit Ambasada Urody Clinic & Spa for a consultation, where our doctors will tailor the therapy to your skin's needs.